studi scientifici internazionali relativi alle nanopatologie

  • February 2007  EPA 100/B-07/001 NANOTECHNOLOGY WHITE PAPER
  • November 2008:  ROYAL COMMISSION ON ENVIRONMENTAL POLLUTION -CHAIRMAN: SIR JOHN LAWTON CBE, FRS-Twenty-seventh Report: Novel Materials in the Environment: The case of nanotechnology – Presented to Parliament by Command of Her Majesty November 2008
  • Nanoparticles: a review of particle toxicology following inhalation exposure
  • Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles

  • A.M. Gatti, M. Ballestri, A. Bagni, Granulomatosis associated to porcelain wear debris,  American Journal of Dentistry  2002, 15(6): 369

  • Nanotoxicology References: A bibliography of references and abstracts of risk-related research studies on nanomaterials compiled by Environmental Defense
  • Translocation of inhaled ultrafine particles to the brain. Inhal.Toxicol 16 , 437-445.

  • Peters K., Unger R.E., Kirkpatrick C.J., Gatti A.M., & Monari E. (2004) Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammation. J.Mater.Sci.Mater.Med. 15, 321-325.

  • Rahman Q., Lohani M., Dopp E., Pemsel H., Jonas L., Weiss D.G., & Schiffmann D. (2002) Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environ.Health Perspect. 110, 797-800.

  • Rajagopalan P., Wudl F., Schinazi R.F., & Boudinot F.D. (1996) Pharmacokinetics of a watersoluble fullerene in rats. Antimicrob.Agents Chemother. 40, 2262-2265.

  • Raloff J. (2005) Nano Hazards: Exposure to minute particles harms lungs, circulatory system. Science News Online 167, 179 Available at
  • M. Ballestri, A.Baraldi, A.M. Gatti, L.Furci, A.Bagni, P.Loria, R.Rapanà, N. Carulli, A.Albertazzi “ Liver and kidney foreign bodies granulomatosis in a patient with malocclusion, bruxism, and worn dental prostheses”  Gastroenterology , 2001, 121; 1234-38)
  •  Oberdorster, G., Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 2001, 74, 1-8.
  • Oberdorster, G., Oberdorster, E., and Oberdorster, J., Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005.
  • Nemmar, A., Hoet, P. H., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., and Nemery, B., Passage of inhaled particles into the blood circulation in humans. Circulation 2002, 105, 411-414.
  •  Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., and Cox, C., Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A 2002, 65, 1531-1543.

  • Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., and Cox, C., Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 2004, 16, 437-445

  • Reichrtova, E., Dorociak, F., and Palkovicova, L., Sites of lead and nickel accumulation in the placental tissue. Hum Exp Toxicol 1998, 17, 176-181

  • Kaiglova, A., Reichrtova, E., Adamcakova, A., and Wsolova, L., Lactate dehydrogenase activity in human placenta following exposure to environmental pollutants. Physiol Res 2001, 50, 525-528

  • Nemmar, A., Hoylaerts, M. F., Hoet, P. H., Dinsdale, D., Smith, T., Xu, H., Vermylen, J., and Nemery, B., Ultrafine particles affect experimental thrombosis in an in vivo hamster model. Am J Respir Crit Care Med 2002, 166, 998-1004

  • Gatti, A. M., Montanari, S., Monari, E., Gambarelli, A., Capitani, F., and Parisini, B., Detection of micro- and nano-sized biocompatible particles in the blood. J Mater Sci Mater Med 2004, 15, 469-472

  • Pope, C. A., 3rd, Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who’s at risk?, Environ Health Perspect 2000, 108 Suppl 4, 713-723

  • Cook-Mills, J. M., and Deem, T. L., Active participation of endothelial cells in inflammation. J Leukoc Biol 2005, 77, 487-495

  •  Montgomery, K. F., Osborn, L., Hession, C., Tizard, R., Goff, D., Vassallo, C., Tarr, P. I., Bomsztyk, K., Lobb, R., Harlan, J. M., and et al., Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Proc Natl Acad Sci U S A 1991, 88, 6523-6527.

  • Roebuck, K. A., Rahman, A., Lakshminarayanan, V., Janakidevi, K., and Malik, A. B., H2O2 and tumor necrosis factor-alpha activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter. J Biol Chem 1995, 270, 18966-18974

  • Mukaida, N., Okamoto, S., Ishikawa, Y., and Matsushima, K., Molecular mechanism of interleukin-8 gene expression. J Leukoc Biol 1994, 56, 554-558.

  • Peters, K., Schmidt, H., Unger, R. E., Otto, M., Kamp, G., and Kirkpatrick, C. J., Software-supported image quantification of angiogenesis in an in vitro culture system: application to studies of biocompatibility. Biomaterials 2002, 23, 3413-3419.

  • A.M. Gatti , F. Rivasi “ Biocompatibility of micro- and nanoparticles Part I in liver and kidney.” Biomaterials  june 2002, vol 23 , issue 11 , 2381-2387

  • A.M. Gatti: Biocompatibility of micro- and nano-particles in the colon (part II)  Biomaterials vol.25, 3, Feb 2004 385-392

  •  Kirkpatrick, C. J., Barth, S., Gerdes, T., Krump-Konvalinkova, V., and Peters, K., [Pathomechanisms of impaired wound healing by metallic corrosion products]. Mund Kiefer Gesichtschir 2002, 6, 183-190.

  • Peters, Unger, Gatti, Monari, Kirkpatrick Effects of nano-scaled particles on endothelial cell function in vitro:Studies on viability, proliferation and inflammation, J. of Material Science: Mat. in Medicine 15 (4),  321-325, 2004.

  • AM. Gatti, Montanari, Monari, Gambarelli, Capitani, Parisini Detection of micro and nanosized biocompatible particles in blood. J. of Mat. Sci. Mat in Med. 15 (4): 469-472, April 2004

  •  AM Gatti Risk assessment of micro and nanoaprticles and the human health, Chapter  of Handbook  of  Nanostructured biomaterials and their applications ed American Scientific Publisher USA 2005, cap. 12, 347-369

  • Gatti AM, Symposium Keynote Presentation “Risk Assessment of Nano-Particles and Nano-Technologies for Human Health. 7th World Biomaterials Congress- Sindney (Australia)  2004 (pag. 748-749).

  • M. Lucarelli, A.M. Gatti, G. Savarino, P. Quattroni, L. Martinelli, E. Monari, D. Boraschi “Innate defence function of macrophages can be biased by nano-sized ceramic and metallic particles”  Cytokin Network, Decembre 2004, Vol 15 No. 4,pag 339-346

  • A. Gatti, S. Montanari, A. Gambarelli, F. Capitani, R. Salvatori “ In-vivo short- and long-term evaluation of the interaction material-blood” Journal of Materials Science Materials in Medicine, 2005, 16, 1213-19.

  • Alargova R.G., Deguchi S., & Tsujii K. (2001) Stable colloidal dispersions of fullerenes in polar

  • organic solvents. J Am Chem.Soc. 123, 10460-10467.

  •  Andrievsky GV, Klochkov VK,BordyuhAB, & Dovbeshko GI (2002) Comparative analysis of two aqueous-colloidal solutions of C-60 fullerene with help of FTIR reflectance and UV-Vis spectroscopy. Chem Phys Lett 364, 8-17.

  •  Bahnemann DW, Kholuiskaya SN, Dillert R, Kulak AI, & Kokorin AI (2002) Photodestruction of dichloroacetic acid catalyzed ny nano-sized TiO2 particles. Appl Catalysis B-Environmental 36,161-169.

  •  Ballou B., Lagerholm B.C., ErnstL.A., Bruchez M.P., & Waggoner A.S. (2004) Noninvasive imaging of quantum dots in mice. Bioconjug.Chem. 15, 79-86.

  •  Beck-Speier I., Dayal N., Karg E., Maier K.L., Roth C., Ziesenis A., & Heyder J. (2001) Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages. Environ.Health Perspect. 109 Suppl 4, 613-618.

  •  Bermudez E., Mangum J.B., Wong B.A., Asgharian B., Hext P.M., Warheit D.B., & Everitt J.I. (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol.Sci. 77, 347-357.

  •  Borm P.J. (2002) Particle toxicology: from coal mining to nanotechnology. Inhal.Toxicol 14, 311-324.

  • Castranova V (2000) From coal mine to quartz: mechanisms of pulmonary pathogenicity nhal.Toxicol 12, 7-14.

  •  Chen HH (1997) Renal effects of water-soluble polyarylsulfonated C-60 inrats with an acute toxicity study. Fullerne Sci tech 5, 1387-1396.

  •  Chen H.H., Yu C., Ueng T.H., Chen S., Chen B.J., Huang K.J., & Chiang L.Y. (1998) Acute and subacute toxicity study of water-soluble polyalkylsulfonated C60 in rats. Toxicol Pathol. 26, 143-151.

  •  Churg A., Stevens B., & Wright J.L. (1998) Comparison of the uptake of fine and ultrafine TiO2 in a tracheal explant system. Am.J.Physiol 274, L81-L86.

  •  Colvin V.L. (2003) The potential environmental impact of engineered nanomaterials. Nat.Biotechnol. 21, 1166-1170.

  • Cui D., Tian F., Ozkan C.S., Wang M., & Gao H. (2005) Effect of single wall carbon nanotubes on human HEK293 cells. Toxicol.Lett. 155, 73-85.

  • Da Ros T & PratoM (1999) Medicinal chemistry with fullerenes and fullerene derivatives. Chem Commun 8, 663-669.

  • Da Ros T., Spalluto G., &PratoM. (2001) Biological Applications of Fullerene Derivatives: A Brief Overview. Croatica Chemica Acta 74, 743-755.

  • Dagani R (2003) Nanomaterials: Safe or unsafe? Chem Eng News 81, 30-33.

  • Deguchi S, Alargova R.G., & Tsujii K. (2001) Stable dispersions of fullerenes, C-60 and C-70, in water. Preparation and Characterization. Langmuir 17, 6013-6017.

  • Derfus A., Chan W., & Bhatia S. (2004) Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Letters 4, 11-18

  •  Foley S.,CrowleyC., Smaihi M., Bonfils C., Erlanger B.F., Seta P., & Larroque C. (2002)

  • Cellular localisation of a water-soluble fullerene derivative. Biochem.Biophys.Res.Commun. 294, 116-119.

  •  Goho A. (2004) Buckyballs at bat: Toxic nanomaterials get a tune-up. Science News Online 166,211. Available at

  • Goho A. (2004) Tiny trouble: Nanoscale materials damage fish brains. Science News Online 165,211. Available at

  • Gorman J. (2002) Taming High-Tech Particles. Science News Online 161, 200. Available at

  • Green M. & Howman E. (2005) Semiconductor quantum dots and free radical induced DNA nicking. Chem Commun 1, 121-123.

  • Gref R., Couvreur P., Barratt G., & Mysiakine E. (2003) Surface-engineered nanoparticles for multiple ligand coupling. Biomaterials 24, 4529-4537.

  • 25. Henry C (2003) Quantum Dot Advances- Studies show that nanoparticles have potential biological application. Chem Eng News 81, 10.

  • Hoet P.H., Bruske-HohlfeldI., & Salata O.V. (2004) Nanoparticles – known and unknown health risks. J.Nanobiotechnology. 2, 12.

  •  Hoshino A., Fujioka K., Oku T., Suga M., Sasaki Y., Ohta T., Yasuhara M., Suzuki K., & Yamamoto K. (2004) Physicochemical Properties and Cellular Toxicity of Nanocrystal Quantum Dots Depend on Their Surface Modification. Nano Letters 4, 2163-2169.

  • Kai Y, Komazawa Y, Miyajima A, Miyata N, & Yamakoshi Y (2003) 60 Fullerene as a novel photoinduced antibiotic. Fuller.Nanotub.Carbon Nanostruc. 11, 79-87.

  • Kamat J.P., Devasagayam T.P., Priyadarsini K.I., Mohan H., & Mittal J.P. (1998) Oxidative damage induced by the fullerene C60 on photosensitization in rat liver microsomes.

  • Chem.Biol.Interact. 114, 145-159.

  • Kleeman MJ, Schauer JJ, & Cass GR (2000) Size and composition distribution of fine particulate matter emitted from motor vehicles. Environ Sci Technol 34, 1132-1142.

  •  Kreuter J., Ramge P., Petrov V., Hamm S., Gelperina S.E., Engelhardt B., Alyautdin R., von Briesen H., & Begley D.J. (2003) Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm.Res. 20, 409-416.

  • Kuhn K.P., Chaberny I.F., Massholder K., Stickler M., Benz V.W., Sonntag H.G., & Erdinger L. (2003) Disinfection of surfaces by photocatalytic oxidation with titanium dioxide and UVA light. Chemosphere 53, 71-77.

  • Lademann J et al (1999) Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol Appl Skin Physiol 12, 247-256.

  • Lam C.W., James J.T., McCluskey R., & Hunter R.L. (2004) Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77, 126-134.

  •  Lecoanet H.F., Bottero J.Y., & Wiesner M.R. (2004) Laboratory assessment of the mobility of nanomaterials in porous media. Environ.Sci.Technol. 38, 5164-5169.

  • Lecoanet H.F. & Wiesner M.R. (2004) Velocity effects on fullerene and oxide nanoparticle deposition in porous media. Environ.Sci.Technol. 38, 4377-4382.

  • Liu Z.S., Tang S.L., & Ai Z.L. (2003) Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human hepatoma BEL-7402 cells. World J Gastroenterol. 9, 1968-1971.

  • Maness P.C., Smolinski S., Blake D.M., Huang Z., Wolfrum E.J., & Jacoby W.A. (1999) Bactericidal activity of photocatalytic TiO(2) reaction: toward an understanding of its killing mechanism. Appl.Environ.Microbiol. 65, 4094-4098.

  • Maynard A.D., Baron P.A., Foley M., Shvedova A.A., Kisin E.R., & Castranova V. (2004) Exposure to carbon nanotube material: aerosol release during the handling of unrefined singlewalled carbon nanotube material. J.Toxicol.Environ.Health A 67, 87-107.

  • Mc-Hedlov-Petrossyan NO K.V.A.G. (1997) Colloidal dispersions of fullerene C-60 inwater: some properties and regularities of coagulation by electrolytes. J Chem Soc- Faraday Trans 93, 4343-

  • 4346.

  • Monti D., Moretti L., Salvioli S., Straface E., Malorni W., Pellicciari R., Schettini G., Bisaglia M., Pincelli C., Fumelli C., Bonafe M., & Franceschi C. (2000) C60 carboxyfullerene exerts a protective activity against oxidative stress-induced apoptosis in human peripheral blood mononuclear cells. Biochem.Biophys. Res. Commun. 277, 711-717.

  • Nagaveni K., Sivalingam G., Hegde M.S., & Madras G. (2004) Photocatalytic degradation of organic compounds over combustion-synthesized nano-TiO2. Environ.Sci.Technol. 38, 1600-1604.

  •  Nakagawa Y., Wakuri S., Sakamoto K., & Tanaka N. (1997) The photogenotoxicity of titanium dioxide particles. Mutat.Res. 394, 125-132.

  • Nakajime N, Nishi C, Li FM, & Ikada Y (1996) Photo-induced cytotoxicity of water-soluble fullerenes. Fullerne Sci tech 4, 1-19.

  •  Oberdorster E. (2004) Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. E viron.Health Perspect. 112, 1058-1062.

  • Oberdorster G. (2001) Pulmonary effects of inhaled ultrafine particles. Int.Arch.Occup.Environ Health 74, 1-8

  • Oberdorster G., Sharp Z., Atudorei V., Elder A., Gelein R., Kreyling W., & Cox C. (2004)

  • Rancan F., Rosan S., Boehm F., Cantrell A., Brellreich M., Schoenberger H., Hirsch A., & Moussa F. (2002) Cytotoxicity and photocytotoxicity of a dendritic C(60) mono-adduct and a malonic acid C(60) tris-adduct on Jurkat cells. J.Photochem.Photobiol.B 67, 157-162.
  • Rincon A.G. & Pulgarin C. (2003) Photocatalytical inactivation of E. coli: effect of (continuousintermittent) light intensity and of (suspended-fixed) TiO2 concentration. Appl Catalysis BEnvironmental 44, 263-284.

  • Sayes C., Fortner J., Guo W., Lyon D., Boyd A., Ausman K., Tao Y., Sitharaman B., Wilson L.,Hughes J., West J., & Colvin V.L. (2004) The Differential Cytotoxicity of Water-Soluble Fullerenes. Nano Letters 4, 1881-1887.

  • Schulz J., Hohenberg H., Pflucker F., Gartner E., Will T., Pfeiffer S., Wepf R., Wendel V., Gers-Barlag H., & Wittern K.P. (2002) Distribution of sunscreens on skin. Adv.Drug Deliv.Rev. 54 Suppl 1, S157-S163.

  • Shiohara A., Hoshino A., Hanaki K., Suzuki K., & Yamamoto K. (2004) On the cyto-toxicity caused by quantum dots. Microbiol.Immunol. 48, 669-675.

  • Shvedova A.A., Castranova V., Kisin E.R., Schwegler-Berry D.,MurrayA.R., Gandelsman V.Z., Maynard A., & Baron P. (2003) Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J.Toxicol.Environ.Health A 66, 1909-1926.

  • Voura E.B., Jaiswal J.K., Mattoussi H., & Simon S.M. (2004) Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat.Med. 10, 993-998

  • Wang I.C., Tai L.A., Lee D.D., Kanakamma P.P., Shen C.K., Luh T.Y., Cheng C.H., & Hwang K.C. (1999) C(60) and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation. J Med.Chem 42, 4614-4620.

  • Warheit D.B., Laurence B.R., Reed K.L., Roach D.H., Reynolds G.A., & Webb T.R. (2004) Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77,117-125.

  • Yang X.L., Fan C.H., & Zhu H.S. (2002) Photo-induced cytotoxicity of malonic acid [C(60)]fullerene derivatives and its mechanism. Toxicol In Vitro 16, 41-46.

  • Zhou G., Duan W., & Gu B. (2004) Single electron emission from the closed-tips of single-walled carbon nanotubes. J.Chem.Phys. 121, 12600-12605.


One thought on “studi scientifici internazionali relativi alle nanopatologie

  1. Pingback: greenwashing | 0co2

Lascia un commento

Inserisci i tuoi dati qui sotto o clicca su un'icona per effettuare l'accesso:


Stai commentando usando il tuo account Chiudi sessione / Modifica )

Foto Twitter

Stai commentando usando il tuo account Twitter. Chiudi sessione / Modifica )

Foto di Facebook

Stai commentando usando il tuo account Facebook. Chiudi sessione / Modifica )

Google+ photo

Stai commentando usando il tuo account Google+. Chiudi sessione / Modifica )

Connessione a %s...